Research Projects
Oral Medicine and Immunizations
- Oral large molecules such as protein, peptide and antibody.
- Oral delivery of anticoagulant to treat thrombosis and cancer mediated thrombosis.
- Oral delivery of PCSK-9 to prevent high cholesterol mediated risk of heart failure.
- Oral delivery of mucoadhesive gel to treat IBD and Crohn’s disease.
Khatun Z, Nurunnabi M, Cho KJ, Bae YH, Byun Y, Lee Y. Oral absorption mechanism and anti-angiogenesis effect of taurocholic acid-linked heparin docetaxel conjugates. Journal of Controlled Release, 2014, 177, 64–73.
[Lee D-Y, Nurunnabi M], Kang SH, Nafiujjaman M, Lee Y, Kim Y. Oral gavage delivery of PR8 antigen with β-glucan conjugated GRGDS carrier enhance M-cell targeting ability and induce immunity. Biomacromolecules, 2017, 18 (4), 1172–1179.
Cell and Sub-cellular Specific Delivery System
- Biomarker mediated cell specific chemotherapeutics delivery.
- Nucleus targeting CRISPR delivery for editing gene in mosquito.
- Mitochondrial targeting treatment for diabetes and anti-aging.
- Knocking in gene to ℬ-cell to enhance insulin secretion to treat type 1 diabetes.
Nurunnabi M, Khatun Z, Badruddoza AZM, McCarthy JR, Lee Y, Huh K. Biomaterials and Bioengineering Approaches for Mitochondria and Nuclear Targeting Drug Delivery. ACS Biomaterials Science & Engineering, 2019, 54, 1645-1660.
Khatun Z, Choi Y. S, Kim Y. G, Nurunnabi M, Li L, Lee E, Kang H. C, Huh K. M. A Bioreducible Poly(ethylene glycol)-Triphenylphosphonium Conjugate as a Bioactivable Mitochondria-Targeting Nano-carrier. Biomacromolecules, 2017, 18 (4), 1074-1085.
Muthiah M, Park S-H. Nurunnabi M, Lee J, Lee Y, B-l Lee, Min J-J, Park I-K. Intracellular delivery and activation of the genetically encoded photosensitizer Killer Red by quantum dots encapsulated in polymeric micelles. Colloids and Surface B. Biointerfaces, 2014, 116, 284–294.
Nurunnabi M, Zehedina K, Moon WC, Lee G, Lee Y. Heparin based nanoparticles for cancer targeting and optical imaging in vivo. Quantitative Imaging in Medicine and Surgery, 2012, 2(3), 219–226.
Bioinspired and Biomimetic Delivery System
- Bioinspired materials to improve drug delivery through minimizing immunogenecity.
- Cell therapy and utilization of cells as a drug carrier.
- Utilizing RBC to target lung diseases- cancer, fibrosis and asthma.
- Development of emulsion and lotion to improve topical delivery of drug to and through the skin for treating skin diseases.
Nurunnabi M, Khatun, Z, Nafiujjaman M, Revuri V, Huh KM, Lee Y. Biological and biomedical application of bile acids. RSC Advances, 2016, 6 (78), 73986-74002.
[Cho MO, Li Z], Shim H-E, Cho I-S, Nurunnabi M, Moon S-H, Kim K-S, Kang S-W, Huh KM. Bioinspired tuning of glycol chitosan for 3D cell culture. NPG Asia Materials, 2016, 8 (9), e309.
[Nurunnabi M, Nafiujjaman M, Lee SJ], Park IK, Huh KM, Lee Y. Exfoliation of ultra-thin hexagonal boron nitride nano-sheets for cancer cell imaging and neurotransmitter sensing. Chemical Communications, 2016, 52, 6146-6149.
Nurunnabi M, Parvez, K, Nafiujjaman M, Revuri V, Feng X, Lee Y. Bioapplication of Graphene Derivatives: Prospects and Challenges. RSC Advances, 2015, 5, 42141-42161.
Nurunnabi M, Khatun Z, Reeck GR, Lee DY, Lee Y. Photoluminescent Graphene Nanoparticles for Cancer Photo-Therapy and Imaging. ACS Applied Materials & Interfaces, 2014, 6, 12413−12421.
Obesity and Diabetes
- Development of materials to treat obesity.
- Identifying and delivering enzyme blocker to control obesity.
- Entrapping fat in the intestine to treat diet induced obesity.
- CRISPR mediated gene knocking in for increasing insulin secretion.
Nurunnabi M, Ibsen KI, Tanner EEL, Mitragotri S. Ionic liquid for the treatment of obesity. Proceedings of the National Academy of Sciences, 2019, 116 (50), 25042-25047.
Nurunnabi M, Lee SA, Revuri V, Cho S, Lee M, Byun Y, Bae YH, Lee DY, Lee Y. Oral gene delivery of GLP1 by riding enterohepatic circulation. Journal of Controlled Release, 2017, 268, 305-313.
Woo HJ, Kim JS, Nurunnabi M, Kim JK, Cho KJ, Huh KM, Lee Y. Preparation and characterization of pioglitazone loaded PLGA nanospheres for the treatment of type 2 diabetes. Polymer-Korea, 2010, 34(6), 527–533.