Research Overview
Our research focuses on developing 3D microphysiological systems with human induced pluripotent stem cell derived cardiovascular/neural tissue models and microfluidic platforms for patient-specific drug discovery, toxicity screening, and fundamental research for precision medicine applications.
Patient-derived 3D engineered cardiac tissue model
- A patient-derived cardiac 3D tissue model.
- Skin cells were isolated from abdominal skin tissue ofa 43 years old female.
- Cells were reprogrammed by transducing theYamanaka factors with sendai virus vectors.
- The established hiPSC were differentiated intocardiomyocytes.
- This model will help in studying cardiotoxicity relatedto anticancer chemotherapy treatment.
Single-Source 3D Blood Brain Barrier Model for Breast Cancer Metastasis Research
- Breast cancer is the second most common cancer thatmetastasizes to the brain, utilizing mechanisms thataren’t fully understood.
- A dual chamber microfluidic device with interconnectingchannels allows for studies of the interaction between ahiPSC-derived blood brain barrier (BBB) and a humanbreast cancer tissue model.
Multi-Wall Microfluidic Device to Promote Muscle Fiber Formation alignment of hiPSC-Derived Cardiomyocytes
- Cardiovascular diseases are the leading cause of death worldwide, and their incidence continues to rise with no indication of decline.
- Multi-Wall Microfluidic device is designed with 6 parallel walls within each dual chamber to promote cardiomyocyte alignment and induce muscle fiber formation.
Multi-Organoid Tri-Chamber Microfluidic Device
- This microfluidic device is designed with three parallelchambers, each containing 12 interconnectedmicrowells to support the growth of multipleorganoids
- Each chamber houses a distinct tissue type includingneural, cardiac, or tumor-associated cells, allowing thesystem to replicate the multi-organ, interconnectedmicroenvironment.
- This setup enables the modeling of a single sourcestem cell-derived neural–cardiac circuit within acancer-associated environment, providing aphysiologically relevant platform to study diseasemechanisms and therapeutic responses.
