Dr. Laura E. O'Dell
My research program is focused on the neural mechanisms that mediate addiction to drugs of abuse. Our laboratory combines neurochemical and molecular approaches with behavioral models in order to provide a better understanding of the neural basis of addiction.
Specific research questions of interest include:
What are the underlying factors that promote tobacco use in vulnerable populations, such as adolescents, females and persons with diabetes?
What are the mechanisms that modulate the neurochemical effects of nicotine and withdrawal from this drug?
What are the biological underpinnings that promote escalation of the intake of drugs of abuse, such as methamphetamine?
Correa, V.L., Flores, R.J., Carcoba, L.M., Garcia-Arreguin, M., and O’Dell, L.E. (2019). Sex differences in cholinergic systems in the interpeduncular nucleus following nicotine exposure and withdrawal.Neuropharmacology,158: 107714. PMID:31325431.
Geste, J., Levin, B., Wilks, I., Pompilus, M., Zhang, X., Esster, K., Febo, M., O'Dell, L.E., and Bruijnzeel, A.W. (2019). Relationship between nicotine intake and reward function in rats with intermittent short versus long access to nicotine. Nicotine and Tobacco Research, in press. PMID:30958557.
Cruz, B., Flores, R.J., Uribe, K.P., Espinosa, E.J., Spencer, C.T., Serafine, K.M., Nazarian, A., O'Dell, L.E. (2019). Insulin modulates the strong reinforcing effects of nicotine and changes in insulin biomarkers in a rodent model of diabetes. Neuropsychopharmacology, 44: 1141-1151. PMID:30647447.
Flores, R.J., Uribe, K.A, and O’Dell, L.E. (2019). Sex differences in nicotine intravenous self-administration: A meta-analytic review. Physiology and Behavior, 203: 42-50. PMID:29158125
Ibias, J., O'Dell, L.E., and Nazarian, A. (2018). Insulin dependent and independent normalization of blood glucose levels reduces the enhanced rewarding effects of nicotine in a rodent model of diabetes. Behavioural Brain Research, 351: 75-82. PMID:29803655
Carcoba, L.M., Flores, R.J., Natividad, L.A., and O’Dell, L.E. (2017). Amino acid modulation of dopamine in the nucleus accumbens mediates sex differences in nicotine withdrawal. Addiction Biology, 23: 1046-1054. PMID:28940989
Pipkin, J.A., Cruz, B., Hinojosa, C.A., Flores, R.J., Carcoba, L.M., Ibarra, M., Francis, W., Nazarian, A., and O’Dell, L.E. (2017). Both nicotine reward and withdrawal are enhanced in a rodent model of diabetes. Psychopharmacology, 234: 1615-1622. PMID:28342091
Gosselink, K.L., D’Arcy, and O’Dell, L.E. (2016). Intermittent vibration increases methamphetamine intake in rats. Journal of Alcoholism, Drug Abuse and Substance Dependence, 2: 5-8.
Carcoba, L.M., Torres, O.V., Pipkin, J.A., Ontiveros, T., and O’Dell, L.E. (2016). Insight into the potential factors that promote tobacco use in vulnerable populations. Current Addiction Reports, 3: 27-36.
Flores, R.J., Pipkin, J.A., Uribe, K.P., Perez, A., and O’Dell, L.E. (2016). Estradiol promotes the rewarding effects of nicotine in female rats. Behavioural Brain Research, 307: 258-263. PMID:27059334
Ph.D., Arizona State University (1997)
PSYC 4324: Psychobiology
PSYC 3346: Drugs of Abuse & Beh.
PSYC 5371: Animal Learning & Beh.
PSYC 5355: Grant Writing
PSYC 5355: Adv. Topics in Neurosci.