Research

Carbon Dots-based Biosensors

The research described here introduces a facile, efficient and cost-effective approach to synthesize boronic acid modified carbon dots with strong photoluminescence property for the recognition of glucose in blood. The objective was accomplished through microwave assisted pyrolysis of citric acid in the presence of 3-aminophenylboronic acid. Under physiological conditions, the carbon dots exhibited an excellent dynamic response to varying concentration of glucose within the biological range (1 -100 mM). In the presence of glucose there was selective assembly and fluorescence quenching of the carbon dots, confirming that the synthesized sensing system was successful in the detection of intracellular glucose. The research underscores that carbon dots conjugated with boronic acid are effective and biocompatible platform with strong selectivity for sensing of glucose.